中图分类号：
R969.2
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参考文献
[1] HU B F, BI H C, HUANG M. Advances in the research of pregnane X receptor and constitutive androstane receptor. Acta Pharm Sin（药学学报）, 2011, 46(10);1173-1177.[2] SUN Y, CHEN X J. Synergistic effect of CYP3A and P-glytoprotein on the first-pass effect of drugs in the intestine. J China Pharm Univ（中国药科大学学报）, 2008, 39(3);285- 288.[3] NELSON D R. Cytochrome P450 and the individuality of species. Arch Biochem Biophys, 1999, 369(1);1- 10.[4] PANG X, CHENG J, KRAUSZ K W. Pregnane X receptor mediated induction of Cyp3a by black cohosh. Xenobiotica, 2011, 41(2);112-123.[5] EDWARDS D P. The role of coactivators and corepressors in the biology and mechanism of action of steroid hormone receptors. J Mammary Gland Biol Neoplasia, 2000, 5(3);307-324.[6] ORANS J, TEOTICO D G, REDINBO M R. The nuclear xenobiotic receptor pregnane X receptor; Recent insights and new challenges. Mol Endocrinol, 2005, 19(12);2891-2900.[7] SONG X, XIE M, ZHANG H, et al. The pregnane X receptor binds to response elementsl in a genomic context-dependent manner, and PXR activator rifmpicin selectively alters the binding among target genes. Drug Metab Dispos, 2004, 32(1);35-42.[8] LIU F J, SONG X, YANG D, et al. The far and distal enhancers in the CYP3A4 gene co-ordinate the proximal promoter in responding similarly to the pregnane X receptor but differentially to hepatocyte nuclear factor-4α. Biochem J, 2008, 409(1);243-250.[9] OWEN A, GOLDRING C, MORGAN P, et al. Induction of P-glycoprotein in lymphocytes by carbamazepine and rifampicin; The role of nuclear hormone response elements. Br J Clin Pharmacol, 2006, 62(2);237-242.
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脚注
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基金
国家自然科学基金资助项目（81102879，81273654）；高等学校博士学科点专项科研基金（20101106120049）；国家科技支撑计划课题(2008BAI51BO2)；国家重大新药创制专项（2013ZX09103002-022，2012ZX09501001）
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